Betamethasone Dipropionate Ointment Usp 0.05 uses and side effects

Betamethasone Dipropionate Ointment contains betamethasone propionate USP, a manufactured Adreno- corticosteroid, for dermatologic use. Betamethasone, a simple of prednisolone, has high corticosteroid movement and slight mineralocorticoid action. Betamethasone propionate is the 17,21-dipropionate ester of betamethasone.

Betamethasone propionate is a white to rich white, unscented crystalline powder, insoluble in water.

Every gram of Betamethasone Dipropionate Ointment 0.05% contains: 0.64 mg betamethasone propionate USP (identical to 0.5 mg betamethasone) in a balm base comprising of mineral oil and white petrolatum.


The corticosteroids are a class of mixes including steroid hormones, discharged by the adrenal cortex and their engineered analogs. In pharmacologic dosages, corticosteroids are utilized principally for their mitigating and/or immunosuppressive impacts.

Topical corticosteroids, for example, betamethasone propionate, are viable in the treatment of corticosteroid-responsive dermatoses fundamentally as a result of their mitigating, antipruritic, and vasoconstrictive activities. In any case, while the physiologic, pharmacologic, and clinical impacts of the corticosteroids are surely understood, the careful systems of their activities in every infection are questionable. Betamethasone propionate, a corticosteroid, has been appeared to have topical (dermatologic) and systemic pharmacologic and metabolic impacts normal for this class of medications.

Pharmacokinetics: The degree of percutaneous assimilation of topical corticosteroids is dictated by numerous elements including the vehicle, the honesty of the epidermal obstruction, and the utilization of occlusive dressings.

Topical corticosteroids can be ingested from typical in place skin. Irritation and/or other malady forms in the skin increment percutaneous ingestion. Occlusive dressings significantly expand the percutaneous assimilation of topical corticosteroids.

Once ingested through the skin, topical corticosteroids are taken care of through pharmacokinetic pathways like systemically regulated corticosteroids. Corticosteroids are bound to plasma proteins in fluctuating degrees. Corticosteroids are metabolized fundamentally in the liver and are then discharged by the kidneys. A portion of the topical corticosteroids and their metabolites are additionally discharged into the bile.

Eighty pediatric patients ages 6 months to 12 years, with atopic dermatitis, were selected in an open name, hypothalamic-pituitary-adrenal (HPA) hub wellbeing study. Betamethasone Dipropionate Ointment was connected twice every day for 2 to 3 weeks over a mean body surface region of 58% (territory 35% to 99%). In 15 of 53 (28%) evaluable patients, adrenal concealment was demonstrated by either a pre-fortified cortisol fixation < 5 mcg/dL pre-incitement cortisol, or a cosyntropin post-incitement cortisol < 18 mcg/dL and an expansion of < 7 mcg/dL from the gauge cortisol. Follow-up testing 2 weeks after study consummation accessible for 2 of the 15 patients showed a typically responsive HPA pivot.

Concentrates on performed with Betamethasone Dipropionate Ointment show that it is in the high scope of intensity as contrasted and other topical corticosteroids.


Betamethasone Dipropionate Ointment is a high-power corticosteroid showed for the help of the provocative and pruritic signs of corticosteroid-responsive dermatoses in patients 13 years and more established.


Betamethasone Dipropionate Ointment is contraindicated in patients who are extremely touchy to betamethasone propionate, to different corticosteroids, or to any fixing in these arrangements.


This data is planned to help in the sheltered and powerful utilization of this solution. It is not an exposure of all conceivable unfriendly or planned impacts.

Patients utilizing topical corticosteroids ought to get the accompanying data and directions:

  1. This pharmaceutical is to be utilized as coordinated by the doctor. It is for outer utilize as it were. Keep away from contact with the eyes.
  2. Patients ought to be prompted not to utilize this drug for any confusion other than that for which it was endorsed.
  3. The treated skin territory ought not to be swathed or generally secured or wrapped as to be occlusive.
  4. Patients ought to report any indications of neighborhood antagonistic responses.
  5. Other corticosteroid-containing items ought not to be utilized with Betamethasone Dipropionate Ointment without first conversing with your doctor.


The accompanying neighborhood antagonistic responses are accounted for occasionally when Betamethasone Dipropionate Ointment is utilized as suggested as a part of the DOSAGE AND ADMINISTRATION segment. These responses are recorded in a surmised diminishing request of the event: blazing, tingling, bothering, dryness, folliculitis, hypertrichosis, acneiform emissions, hypopigmentation, perioral dermatitis, unfavorably susceptible contact dermatitis, maceration of the skin, auxiliary disease, skin decay, striae, miliaria.

Unfriendly responses answered to be conceivably or most likely identified with treatment with betamethasone propionate salve amid a pediatric clinical study incorporate indications of skin decay (telangiectasia, slenderness, sparkle, wounding, loss of skin markings). The cutaneous decay of the face happened in 1/6 (17%) of newborn children, 2/9 (22%) of 2-5-year-olds, and 2/6 (33%) of the 6-8-year-olds. Non-facial decay happened in 15%, 8%, and 9% of 2-5-year-olds, 6-8-year-olds, and 9-12-year-olds, individually. Systemic ingestion of topical corticosteroids has created reversible hypothalamic-pituitary-adrenal (HPA) hub concealment, signs of Cushing’s disorder, hyperglycemia, and glucosuria in a few patients.

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